[HTML][HTML] Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of …
B Chen, Y Feng, M Zhang, G Cheng… - American Journal of …, 2019 - ncbi.nlm.nih.gov
The direct interaction between Cullin 4B (CUL4B) and DNA damage-binding protein 1
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which
are involved in the tumorigenesis of osteosarcoma through ubiquitinating and degrading
multiple tumor suppressors and cell cycle regulators. Thus, targeting CUL4B-DDB1
interaction to prevent the assembly of CRL4B may be a potent approach to inhibit
osteosarcoma cell growth. In the present study, we identified six naturally-sourced small …
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which
are involved in the tumorigenesis of osteosarcoma through ubiquitinating and degrading
multiple tumor suppressors and cell cycle regulators. Thus, targeting CUL4B-DDB1
interaction to prevent the assembly of CRL4B may be a potent approach to inhibit
osteosarcoma cell growth. In the present study, we identified six naturally-sourced small …
